Antiproliferation Activities of Indonesian Java Chili, Piper Retrofractum Vahl., Against Breast Cancer Cells (Mcf-7)
A. E. Z. Hasan, A. Setiyono, and J.J. Silip

Source: SEAMEO BIOTROP's Research Grant | 2014


Cancer is a major killer in the world.  Breast cancer is the first rank in the number of patients treated in Indonesia (28%), followed by cervical cancer (12%).  Piperine is an active component in Java chili fruit (Piper retrofractum Vahl.) that serves as an anticancer ingredient.  By extracting fruit Java chili and tested in vitro against breast cancer cells MCF-7 by means of the MTT-assay.  From fifth locations Java chilies example of this research.  Based on the analysis of phytochemicals, all Java chili extract contains flavonoids and alkaloids in addition to steroids.  Java chili fruits extract the highest anticancer activeness as indicated by the Java chili fruits extract derived from Air Naningan 2 Lampung with IC50 value of 4.35 µg/ml. 

Key words : Java Chili, anticancer, Piper retrofractum, MCF-7

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